abstract：:Cerebral malaria (CM) is the severe neurological complication associated with Plasmodium falciparum infection. In clinical settings CM is predominantly characterized by fever, epileptic seizures, and asexual forms of parasite on blood smears, coma and even death. Cognitive impairment in the children and adults even af...

journal_title：Brain research bulletin

authors： Vanka R,Nakka VP,Kumar SP,Baruah UK,Babu PP

更新日期：2020-04-01 00:00:00

abstract：:Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...

journal_title：Brain research bulletin

authors： Liu L,Liu Y,Li N,Huang R,Zheng X,Huang L,Hou S,Yuan Q

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Transcranial near-infrared stimulation (tNIRS) can penetrate the scalp and skull and can reach the superficial layers of the cerebral cortex. In this study, we evaluated whether an 820-nm tNIRS can modulate the excitability of the primary motor cortex (M1) as measured by transcranial magnetic stimulation (TMS...

journal_title：Brain research bulletin

authors： Song P,Han T,Lin H,Li S,Huang Q,Dai X,Wang R,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:Depression and anxiety have been reported as the major neuropsychiatric consequences following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms in patients with major depressive disorders and anxiety-like symptoms. In addition, minocycline demonstrated efficacy and seemed a promising neuro...

journal_title：Brain research bulletin

authors： Camargos QM,Silva BC,Silva DG,Toscano ECB,Oliveira BDS,Bellozi PMQ,Jardim BLO,Vieira ÉLM,de Oliveira ACP,Sousa LP,Teixeira AL,de Miranda AS,Rachid MA

更新日期：2020-02-01 00:00:00

abstract：:Thyroid hormones are essential for neonatal brain development. It is well established that absence of thyroid hormones during critical periods of development can alter sensory functions such as visual and auditory processing, but there are few studies on rat somatosensory system development at mild, long-term, and irr...

journal_title：Brain research bulletin

authors： Afarinesh MR,Shafiei F,Sabzalizadeh M,Haghpanah T,Taheri M,Parsania S,Golshan F,Sheibani V

更新日期：2020-02-01 00:00:00

abstract：:Vagal nerve stimulation (VNS) is known as an effective method of treatment in a number of neurological disorders. The low risk of side effects also makes it useful in clinical trials in other diseases. Branches of the vagal nerve innervate the anatomical structures known to be involved in memory processing. That is wh...

journal_title：Brain research bulletin

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Kulbat-Warycha K,Konopacki J

更新日期：2020-02-01 00:00:00

abstract：:Single-nucleotide polymorphism (SNP) and Alternative splicing (AS) were found to be implicated in certain diseases, nevertheless, the contributions of mRNA SNPs and AS to pathogenesis in developing rat brains with hypoxic-ischemic encephalopathy (HIE) remained largely vague. Additionally, the disease associated with T...

journal_title：Brain research bulletin

authors： Xue LL,Wang F,Xiong LL,Du RL,Zhou HL,Zou Y,Wu MX,Yang MA,Dai J,He MX,Wang TH

更新日期：2020-01-01 00:00:00

abstract：:Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family and is widely expressed in the central nervous system (CNS). However, it is not clear how the working mechanism of FGF9 is involved in cerebellar development. To address this question, we deleted the Fgf9 gene specifically in GABAergi...

journal_title：Brain research bulletin

authors： Guo M,Chen H,Duan W,Li Z,Li Y,Ma Y,Xu X,Yi L,Bi Y,Liu Y,Zhang J,Li C

更新日期：2020-01-01 00:00:00

abstract：:Cranioplasty is a challenge to neurosurgeons, especially considering protection of intracranial contents. In recent years, material choice for cranioplasty is still controversial, which brings complexity to this seemingly straightforward procedure. PEEK, a tough, rigid, biocompatible material, has been used more recen...

journal_title：Brain research bulletin

authors： Zhang J,Tian W,Chen J,Yu J,Zhang J,Chen J

更新日期：2019-11-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a devastating subtype of stroke because it has few viable therapeutic options to intervene against primary or second brain injury. Recently, evidence has suggested that ferroptosis, a nonapoptotic form of cell death, is involved in ICH. In this study, we examined whether ICH-induced n...

journal_title：Brain research bulletin

authors： Chen B,Chen Z,Liu M,Gao X,Cheng Y,Wei Y,Wu Z,Cui D,Shang H

更新日期：2019-11-01 00:00:00

abstract：:Stroke is one of the leading causes of mortality and morbidity worldwide. Due to its poor prognosis, there is a major negative impact on the patients and their family's life quality. However, despite the severity of this pathology tissue plasminogen activator (tPA) is the only FDA approved treatment for ischemic strok...

journal_title：Brain research bulletin

authors： Bruch GE,Fernandes LF,Bassi BLT,Alves MTR,Pereira IO,Frézard F,Massensini AR

更新日期：2019-10-01 00:00:00

abstract：:Seizure activity stimulates adult neurogenesis, the birth of new neurons, in the hippocampus. Many new neurons that develop in the presence of repeatedly induced seizures acquire abnormal morphological and functional characteristics that can promote network hyperexcitability and hippocampal dysfunction. However, the i...

journal_title：Brain research bulletin

authors： Kalinina A,Maletta T,Carr J,Lehmann H,Fournier NM

更新日期：2019-10-01 00:00:00

abstract：:Chronic social stress and/or pharmacological treatments differentially modulate the expression of c-Fos, a marker of neuronal activity, in subregions of the rat brain. Here, we examined the effect of the atypical antipsychotic Clozapine (Clz) (20 mg/kg/day for 3 weeks) on the neuronal activation pattern of c-Fos prote...

journal_title：Brain research bulletin

authors： Stanisavljević A,Perić I,Bernardi RE,Gass P,Filipović D

更新日期：2019-10-01 00:00:00

abstract：:Pax6 is an important transcription factor expressed in several discrete domains of the developing central nervous system. It has been reported that Pax6 is involved in the specification of subtypes of hindbrain motor neurons. Pax6 homozygous mutant (rSey2/rSey2) rats die soon after birth, probably due to impaired resp...

journal_title：Brain research bulletin

authors： Ikeda K,Onimaru H,Inada H,Tien Lin S,Arata S,Osumi N

更新日期：2019-10-01 00:00:00

abstract：:Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries like multiple sclerosis (MS), spinal cord injury, stroke, and virus-induced encephalopathy. Myelination is essential for efficacious neuronal signaling. This myelination process is origi...

journal_title：Brain research bulletin

authors： Unal DB,Caliari SR,Lampe KJ

更新日期：2019-10-01 00:00:00

abstract：:The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...

journal_title：Brain research bulletin

authors： Huang L,Otrokocsi L,Sperlágh B

更新日期：2019-09-01 00:00:00

abstract：:Retinal injuries and diseases are major causes of human disability involving vision impairment by the progressive and permanent loss of retinal neurons. During development, assembly of this tissue entails a successive and overlapping, signal-regulated engagement of complex events that include proliferation of progenit...

journal_title：Brain research bulletin

authors： Ventura ALM,Dos Santos-Rodrigues A,Mitchell CH,Faillace MP

更新日期：2019-09-01 00:00:00

abstract：:Interleukin-33 (IL-33) is closely related to the regulation of immunological cells, and its receptor ST2 is a member of the interleukin-1 (IL-1) receptor family. Inflammatory responses play critical roles in neuronal damage and white matter injury (WMI) post intracerebral hemorrhage (ICH). In this study, we tried to e...

journal_title：Brain research bulletin

authors： Chen Z,Xu N,Dai X,Zhao C,Wu X,Shankar S,Huang H,Wang Z

更新日期：2019-08-01 00:00:00

abstract：:The regeneration of brain tissue remains one of the greatest unsolved challenges in medicine and by many is considered unfeasible. Indeed, the adult mammalian brain does not regenerate tissue, but there is ongoing endogenous neurogenesis, which is upregulated after injury and contributes to tissue repair. This endogen...

journal_title：Brain research bulletin

authors： Modo M,Badylak SF

更新日期：2019-08-01 00:00:00

abstract：:Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable ...

journal_title：Brain research bulletin

authors： de Abreu MS,Giacomini ACVV,Sysoev M,Demin KA,Alekseeva PA,Spagnoli ST,Kalueff AV

更新日期：2019-05-01 00:00:00

abstract：:Regenerative medicine strategies rely on exogenous cell transplantation and/or endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of cells and biomolecules by controlling transplanted cell fate and provide a local, sustained release of biomolecules. In this review, we describe th...

journal_title：Brain research bulletin

authors： Ho MT,Teal CJ,Shoichet MS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) refers to the delivery of electric current to specific deep brain structures through implanted electrodes. Recently approved for use in United States, DBS to the anterior nucleus of thalamus (ANT) is a safe and effective alternative treatment for medically refractory seizures. De...

journal_title：Brain research bulletin

authors： Gimenes C,Malheiros JM,Battapady H,Tannus A,Hamani C,Covolan L

更新日期：2019-04-01 00:00:00

abstract：:Early life Stress is a worldwide concern linked with development of later life neurological disorders. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounter...

journal_title：Brain research bulletin

authors： Sarkar T,Patro N,Patro IK

更新日期：2019-04-01 00:00:00

abstract：:The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site and signaling pathways different from Substance P (SP). NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalges...

journal_title：Brain research bulletin

authors： Hunyady Á,Hajna Z,Gubányi T,Scheich B,Kemény Á,Gaszner B,Borbély É,Helyes Z

更新日期：2019-04-01 00:00:00

abstract：:Cerebral ischemia is one of the leading causes of death and long-term disability worldwide. N-myc downstream-regulated gene 4 (NDRG4) is predominantly expressed in the brain as well as in the heart and has been reported to be involved in resistance to neuronal cell death caused by ischemic injury. However, the underly...

journal_title：Brain research bulletin

authors： Wen L,Liu L,Li J,Tong L,Zhang K,Zhang Q,Li C

更新日期：2019-03-01 00:00:00

abstract：:Reticulons (RTNs) are a group of membrane-bound proteins that are dominantly localized to the endoplasmic reticulum (ER). RTN1-C, one isoform of RTNs highly expressed in the brain, has been shown to mediate neuronal injury in cerebral ischemia models. The aim of this study was to investigate the role of RTN1-C in an i...

journal_title：Brain research bulletin

authors： Chang J,Zhang XL,Yu H,Chen J

更新日期：2019-03-01 00:00:00

abstract：:Clinical and pre-clinical evidences indicate an association between inflammation and depression since increased levels of pro-inflammatory cytokines are associated with depression-related symptoms. Atorvastatin is a cholesterol-lowering statin that possesses pleiotropic effects including neuroprotective and antidepres...

journal_title：Brain research bulletin

authors： Taniguti EH,Ferreira YS,Stupp IJV,Fraga-Junior EB,Doneda DL,Lopes L,Rios-Santos F,Lima E,Buss ZS,Viola GG,Vandresen-Filho S

更新日期：2019-03-01 00:00:00

abstract：:Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L, has been found to exert neuroprotective, anti-decrepitude, and anti-inflammatory ac...

journal_title：Brain research bulletin

authors： Du Y,Li W,Li Y,Yang J,Wang X,Yin S,Wang X,Velez de-la-Paz OI,Gao Y,Chen H,Yin X,Shi H

更新日期：2019-03-01 00:00:00

abstract：:Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the ...

journal_title：Brain research bulletin

authors： Leal PC,Bispo JMM,Lins LCRF,Souza MF,Gois AM,Moore C,Marchioro M,Ribeiro AM,Silva RH,Meshul CK,Santos JR

更新日期：2019-03-01 00:00:00

abstract：:Cardiolipin is a mitochondrial membrane phospholipid with several well-defined metabolic roles. Cardiolipin can be released extracellularly by damaged cells and has been shown to affect peripheral immune functions. We hypothesized that extracellular cardiolipin can also regulate functions of microglia, the resident im...

journal_title：Brain research bulletin

authors： Pointer CB,Wenzel TJ,Klegeris A

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Traditional Medicine Practices (TMP) which are premised on indigenous knowledge and experiences within a local context of the culture and environment, are common place in low income countries. In Africa and in Uganda specifically, nearly 80% of the Ugandan population relies on TMP for the care of their menta...

journal_title：Brain research bulletin

authors： Abbo C,Odokonyero R,Ovuga E

更新日期：2019-02-01 00:00:00

abstract：:Increasing evidence supports that dopamine (DA) plays an important role in the hippocampal function via activation of D1-like receptors (D1Rs). As the entry structure of the hippocampal formation, the hippocampal dentate gyrus (DG) is critically involved in spatial learning and memory. Despite a number of studies inve...

journal_title：Brain research bulletin

authors： Wang F,Wan P,Wang W,Xiao B,Jin H,Jin Q

更新日期：2019-01-01 00:00:00

abstract：:Diminished sensitivity to kainic acid (KA) lesioning action is present in the hippocampus of the lactating dam. Given that KA can alter blood-brain barrier (BBB) permeability, we investigated whether lactation would protect BBB permeability after treatment with this neurotoxin. Adult virgin or lactating (13-15 days pp...

journal_title：Brain research bulletin

authors： Solís CD,Morales T

更新日期：2019-01-01 00:00:00

abstract：:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function...

journal_title：Brain research bulletin

authors： Mueller PL,Pritchett CE,Wiechman TN,Zharikov A,Hajnal A

更新日期：2018-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a worldwide progressive neurodegenerative disorder in the elderly. Previous research has indicated that Alzheimer's disease impairs white matter (WM) tracts. Anatomical and neuroimaging studies have indicated that WM tracts are associated with cognitive function. Whether the abnormal WM int...

journal_title：Brain research bulletin

authors： Li Y,Feng F,Lin P,Huang ZG,Liu T,Zhou B,Yao H,Zheng L,Li C,Wang P,Zhang Z,Guo Y,Wang L,An N,Zhu X,Zhang X,Wang J

更新日期：2018-10-01 00:00:00

abstract：:Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as effective neuroprotective factors in several neurological disorders. The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetraz...

journal_title：Brain research bulletin

authors： Mansoor SR,Hashemian M,Khalili-Fomeshi M,Ashrafpour M,Moghadamnia AA,Ghasemi-Kasman M

更新日期：2018-09-01 00:00:00

abstract：:Diabetes mellitus (DM) is considered the primary cause of neuropathic pain. Osthole (7-methoxy-8[3-methylpent 2-enyl]coumarin) is a component extracted from Cnidium monnieri (L.) cusson plant seeds and has anti-inflammatory and anti-oxidative properties. The aim of the present study was to investigate the effects of o...

journal_title：Brain research bulletin

authors： Yuan H,Ouyang S,Yang R,Li S,Gong Y,Zou L,Jia T,Zhao S,Wu B,Yi Z,Liu H,Shi L,Li L,Gao Y,Li G,Xu H,Liu S,Zhang C,Liang S

更新日期：2018-09-01 00:00:00

abstract：:The neural substrate of anxiety response (state anxiety) to a threatening situation is well defined. However, a lot less is known about brain structures implicated in the individual's predisposition to anxiety (trait anxiety). Scientific evidences lead us to suppose that the medial prefrontal cortex (mPFC) is involved...

journal_title：Brain research bulletin

authors： Goes TC,Almeida Souza TH,Marchioro M,Teixeira-Silva F

更新日期：2018-09-01 00:00:00

abstract：:Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antin...

journal_title：Brain research bulletin

authors： Sousa FSS,Birmann PT,Baldinotti R,Fronza MG,Balaguez R,Alves D,Brüning CA,Savegnago L

更新日期：2018-09-01 00:00:00

abstract：:The drug delivery across the brain has always been problematic due to the tight junction present namely the blood brain barrier (BBB). BBB only allows selected pharmaceutical drugs to get across it and reach the brain via lipid free diffusion process and exert their therapeutic effect. This leads to the decrease in dr...

journal_title：Brain research bulletin

authors： Nabi B,Rehman S,Khan S,Baboota S,Ali J

更新日期：2018-09-01 00:00:00